Shingles cases dropping among people who got chickenpox vaccine, data shows

The chickenpox vaccine appears to protect against shingles, according to a large new analysis.

Anyone who got infected with chickenpox as a child is at risk of later developing shingles, a painful, blistering rash that usually appears on one side of the body. For unknown reasons, cases of shingles have been gradually rising, even among younger adults, research has shown.

However, new data suggests that a steep decline in chickenpox cases over the last three decades, thanks to the chickenpox vaccine, may contribute to a decline in shingles in the coming years.

New data suggests that people ages 34 and younger may be less likely to develop shingles than previous generations. That’s because they are more likely to have been vaccinated against the varicella zoster virus, or chickenpox, which can reactivate years later as shingles.

“Our data suggest that trend is now reversing in the very youngest adults, the first generation eligible to be vaccinated against chickenpox as children,” said registered nurse Kersten Bartelt, lead author of the report from Epic Research, which conducts research on health trends.

Epic researchers used electronic health data from more than 85 million patients seen by healthcare providers in the United States. They logged shingles diagnoses between 2019 and 2026 and how many cases occurred in different age groups.

The report, which was released Friday, found:

• Shingles cases dropped from 10.8 to 7.3 per 10,000 people for women ages 30 to 34 between 2019 and 2026, and fell from 11 to 7.3 for men in the same age group.
• Among 25- to 29-year-olds, rates of shingles cases more than halved, from 7.7 per 10,000 women and 7.5 per 10,000 men in 2019 to 3.2 and 3.0, respectively.
• In 18- to 24-year-olds, shingles dropped from 2.9 to 1.6 per 10,000 women and from 2.7 to 2.4 per 10,000 men.

It’s a promising development, though because shingles is typically rare in people younger than 50, the data can’t prove whether the protection will last as they age, Bertelt said.

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Still, the new data suggests potential lifelong benefits of chickenpox vaccination.

The Food and Drug Administration approved the first chickenpox vaccine in 1995, when it was added to the childhood vaccination schedule. In 1997, states began requiring it for school and daycare. The Centers for Disease Control and Prevention currently recommends two doses of the varicella vaccine for children from ages 1 to 6.

Since then, infections have plummeted by 97%, according to the CDC. A type of herpes virus that once killed as many as 150 children a year, chickenpox has been virtually wiped out by vaccination, experts say.

“People who have had the chickenpox virus have a higher risk of developing shingles,” said Dr. Sharon Curhan, a physician and epidemiologist at Brigham and Women’s Hospital and Harvard Medical School in Boston, who was not involved in the study. “People who got the vaccine, while they could get shingles, are at much lower risk.”

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The Epic data also showed that rates of shingles are rising among people 35 and over, who are more likely to have had the chickenpox infection as children.

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There’s no clear evidence for what’s causing the rise in this group, but, ironically, it could be linked to the near elimination of the varicella zoster virus, experts say.

“Before the vaccine was available, parents in their 20s, 30s, 40s, and grandparents, were exposed to younger children with chickenpox, so that was like a booster for them,” Curhan said.

Other potential causes are higher rates of chronic stress, depression and anxiety, as well as autoimmune diseases, which weaken the immune system, Curhan said.

Both shingles and chickenpox usually clear up on their own within a couple of weeks, although the virus that causes both infections can cause serious complications, said Dr. Anne Gershon, a professor emeritus of pediatrics at Columbia University medical school, who was not involved in the research.

The most common is severe long-term nerve pain, a condition called postherpetic neuralgia. If a shingles outbreak occurs close to the eye, it can cause blindness, Bartelt said.

Shingles infections have also been linked to a 20% higher risk of cognitive decline — potentially because the virus can reactivate in the head rather than cause a skin rash, said Gershon — as well as increased risk of stroke and heart disease.